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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 35, 2006 - Issue 3-4
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More Than Structural Cells, Fibroblasts Create and Orchestrate the Tumor Microenvironment

Carolyn J. Baglole Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,
,
Denise M. Ray Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,
,
Steven H. Bernstein Lymphoma Biology Program, James P. Wilmot Cancer Center, Rochester, New York, USA
,
Steven E. Feldon Department of Ophthalmology, University of Rochester School of Medicine and Dentistry,
,
Terry J. Smith Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
,
Patricia J. Sime Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry,
&
Richard P. Phipps Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Department of Ophthalmology, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,; Lymphoma Biology Program, James P. Wilmot Cancer Center, Rochester, New York, USACorrespondence[email protected]
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Pages 297-325 | Published online: 07 Jul 2009
 
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Abstract

The tumor microenvironment comprises many cell types including infiltrating immune cells such as lymphocytes, endothelial cells and a complex stroma consisting mainly of fibroblasts. Fibroblasts are heterogeneous and consist of Thy-1+ and Thy-1− subsets that define different biosynthetic and differentiation potential. They produce mediators linked to carcinogenesis and metastasis, including Cox-2 and PGE2, both of which are also increased in most cancers. This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses.

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