Meta-Analysis of the Relationship between TNF-α (−308G/A) and IL-10 (−819C/T) Gene Polymorphisms and Susceptibility to Dengue

ABSTRACT

Objective: This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue.

Methods: a systematic review with meta-analysis was conducted of the associations between the TNF-α (−308G/A) and IL-10 (−819C/T) polymorphisms and dengue.

Results: A total of eight case-controls studies involving 384 individuals with symptomatic dengue, 571 individuals with dengue hemorrhagic fever, and 995 healthy controls were considered in the meta-analysis. There was no significant association between TNF-α (−308G/A) and IL-10 (−819C/T) polymorphism and dengue in overall population. However, stratifying meta-analysis by groups, the meta-analysis revealed association between the TNF-α −308 G/G (OR: 1.62, CI: 1.02–2.57, p = 0.04) genotype and allele G (OR: 1.62, CI: 1.04–2.55, p = 0.03) that confers susceptibility to symptomatic dengue, while the TNF-α −308 G/A genotype (OR: 0.69, CI = 0.39–0.99, p = 0.04) and allele A (OR: 0.64, CI: 0.41–1.00, p = 0.05) confers protection to symptomatic dengue. No difference was observed for the TNF-α (−308) and IL-10 (−819C/T) polymorphisms in the comparisons of hemorrhagic dengue versus control and hemorrhagic dengue versus symptomatic dengue.

Conclusion: This meta-analysis showed that TNF-α (−308) polymorphism is associated with dengue symptomatic susceptibility.

KEYWORDS:

• Dengue
• interleukin-10
• meta-analysis
• polymorphism
• TNF-alpha

Declaration of interest

The authors declare that there are no conflicts of interest.

Funding

This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo à Pesquisa de Alagoas (FAPEAL), nº protocol: 20110906-011-0025-0080. The authors acknowledge to Laboratory Municipal de Arapiraca – AL and Laboratory de Analysis Clinics Dr. Edler Lins (LACEL).

Additional information

Funding

This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo à Pesquisa de Alagoas (FAPEAL), nº protocol: 20110906-011-0025-0080. The authors acknowledge to Laboratory Municipal de Arapiraca – AL and Laboratory de Analysis Clinics Dr. Edler Lins (LACEL).