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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 47, 2018 - Issue 7
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Original Articles

Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis

, , ORCID Icon, , , & show all
Pages 680-688 | Published online: 09 Jul 2018
 

ABSTRACT

Background: Recurrent aphthous stomatitis (RAS) is a common oral condition with a major impact on the quality of life. The condition is thought to be due to the overexpression of T helper-1(Th1)-related cytokines. Since interleukin-4 (IL-4) and its receptor (IL-4Rα) are antagonistic to Th-1 pathways, polymorphisms in their genes may also be involved in the pathogenesis of aphthous stomatitis.

Methods: Sixty-four patients diagnosed with minor RAS and 141 (age- and sex-matched) healthy controls were assessed for 3 single-nucleotide polymorphisms (SNPs) within the promoter region of the IL-4 gene (−1098G/T, −590C/T, and −33C/T), and 1 SNP in IL-4Rα gene (+1902 A/G).

Results: No significant differences were detected between the patient and the control group regarding IL-4 allele frequencies. However, the patient group demonstrated a higher frequency of IL-4 −590 CC genotype and a lower rate of IL-4 −590 TC genotype.

The TCT, GTT, GCT, and GTC haplotypes of the IL-4 gene (−1098, −590, −33) were significantly more frequent in the patients and the GCC, and TTT haplotypes were more common in healthy controls. No significant differences were found in IL-4Rα gene polymorphism between the 2 groups.

Conclusions: Certain polymorphisms of IL4 gene could predispose individuals to RAS.

Acknowledgments

This article has no funding source. The authors have no conflict of interest to declare.

The article has never been presentation anywhere else.

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