Upregulation of TIGIT and PD-1 in Colorectal Cancer with Mismatch-repair Deficiency

ABSTRACT

Background: The role of T cell Ig and ITIM domain (TIGIT) and programmed cell death-1 (PD-1) in colorectal cancer (CRC) with mismatch repair deficiency is unknown.

Methods: This was a study of 60 CRC patients with mismatch repair deficiency and 30 healthy controls between June 2015 and October 2015.

Results: The expression of Foxp3, PD-1, and TIGIT was higher in cancer tissues compared with adjacent mucosa (all P < .05). Patients with advanced TNM stage had a significantly higher expression of TIGIT (P = .025) and PD-1 (P = .020) than patients with early-stage CRC. The disease-free survival (DFS) of patients with high TIGIT (HR = 3.96, 95%CI: 1.34–11.69, P = .013) or PD-1 (HR = 214.8, 95%CI: 49.88–925.2, P < .001) expression were better. The overall survival (OS) of the patients with CRC and high expression of PD-1 was worse than those with low expression (HR = 4.01, 95%CI:1.26–12.69, P = .019).

Conclusion: TIGIT and PD-1 are upregulated in CRC with mismatch repair deficiency and associated with TNM stage and DFS.

KEYWORDS:

• TIGIT
• PD-1
• regulatory T cells
• mismatch-repair deficiency
• colorectal cancer

Competing interests

The authors declare that they have no competing interests.

Data availability statement

Data sharing is not applicable to this article, as no new data were created or analyzed in this study.

Additional information

Funding

This work was supported by the Research and Development Plan of the 13th Five-year Plan of Ningxia Autonomous Region, Grant/Award Number: 2016BZ02; The First Class Discipline Construction Project in Colleges and Universities of Ningxia, Grant/Award Number:NXYLXK2017A05; Ningxia Natural Science Foundation of 2019, Ningxia, Grant/Award Number:2019AAC03116 and Major Project of Intestinal Microecology in General Hospital of Ningxia Medical University. Grant/Award Number:01.