Relationship between the Monocyte Chemo-attractant Protein-1 gene rs1024611 A>G Polymorphism and Cancer Susceptibility: A Meta-analysis Involving 14,617 Subjects

ABSTRACT

Background

Inflammatory and inducible chemokines are the hallmarks of malignancy. Monocyte chemo-attractant protein-1 (MCP-1) is a crucial chemokine implicated in infection and inflammation. Methods: We performed an updated meta-analysis of thirty independent case-control studies with 6,777 cancer cases and 7,840 controls to determine if the MCP-1 gene rs1024611 A > G variant is associated with the risk of cancer. Results: The G allele carriers of rs1024611 in the MCP-1 gene might have a null association with cancer risk in overall comparison. In a subgroup analysis by ethnicity, we identified a marked association between the MCP-1 G allele rs1024611 polymorphism and cancer risk in the Caucasian populations (GG vs. AA: OR = 1.72, 95% CI, 1.12–2.64, P = .013, and GG vs. AG/AA: OR = 1.82, 95% CI, 1.19–2.78, P = .006). The potential bias in literature selection was witnessed in this meta-analysis (G vs. A: P _Begg’s =  0.187, P_Egger’s =  0.049; and GG/GA vs. AA: P _Begg’s =  0.069, P_Egger’s =  0.024). The adjusted ORs and CIs of the nonparametric “trim-and-fill” method demonstrated the reliability of these findings. The outcome of heterogeneity analysis indicated that heterogeneity might be due to small sample sizes (<1000 subjects), cancer types (bladder cancer, other cancers), ethnicity (Asians), and population-based studies. However, the sensitivity analysis validated the reliability of the findings. Conclusion: In conclusion, this updated meta-analysis showed that the G carrier of the MCP-1 gene rs1024611 is associated with susceptibility to cancer in Caucasian.

KEYWORDS:

• Monocyte chemoattractant proteins
• polymorphism
• meta-analysis
• neoplasm
• risk factors

Acknowledgments

We thank Dr. Yan Liu (Genesky Biotechnologies Inc., Shanghai, China) for technical support.

Disclosure of potential conflicts of interests

The authors declare that they have no potential financial conflicts of interest.

Supplementary material

Supplemental data for this article can be accessed on the publisher’s website.

Additional information

Funding

This study was supported by National Natural Science Foundation of China [Grant No.81773129]; Young and Middle-aged Talent Training Project of Health Development Planning Commission in Fujian Province [2016-ZQN-25];Program for New Century Excellent Talents in Fujian Province University [NCETFJ-2017B015];Joint Funds for the innovation of science and Technology, Fujian province [Grant number:2017Y9099, 2017Y9039] The Fujian Provincial Natural Science Foundation[2017J01291];Startup Fund for scientific research, Fujian Medical University [Grant number:2017XQ2027];Changzhou High-Level Medical Talents Training Project [No:2016CZBJ043];the Applied Basic Research Programs of ChangZhou [CJ20159030].