https://orcid.org/0000-0002-9559-1143
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ABSTRACT
Introduction
The association between interleukin(IL)-17A and IL-17 F gene polymorphism with rheumatoid arthritis (RA) were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17 F gene polymorphism with RA.
Methods
We searched Medline up to February 2020. Meta-analyses were performed for the comparisons of allele and multiple genetic models, including dominant, recessive, heterozygous, and homozygous models using fixed or random effects models. Odds ratios (OR) with 95% confidence intervals (95%CI) were utilized to assess the potential relationship.
Results
A total of 2315 confirmed cases and 2342 controls were included from eligible 10 case–controls studies. Meta analysis suggested that rs2275913 G allele increased the risk of RA in Caucasians (G vs A: OR = 1.14, 95% CI = 1.00–1.29, P = .044), but not in Mongolians (P > .05). Pooled analysis suggested that a significant associations between rs763780 C allele with RA susceptibility (C vs T: OR = 1.83, 95% CI = 1.13–2.97, P = .014). Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to RA risk in two races (P < .001). TSA plot revealed that the present study sufficient to draw a conclusion.
Conclusions
This meta-analysis demonstrates IL-17A and IL-17 F genes play a significant role in RA, but its role in Mongolian populations needs further exploration.
Disclosure statement
Ming Shao, Wei Xu, Hui Yang, Yuting Chen, Xing Gao, Shanshan Xu, Shengqian Xu, Zongwen Shuai and Faming Pan declare that they have no conflict of interest.