Association of the IL-6 Rs1800796 SNP with Concentration/dose Ratios of Tacrolimus and Donor Liver Function after Transplantation

ABSTRACT

Interleukin-6 (IL-6) is a proinflammatory cytokine that plays a range of important roles such as in inflammation, immune response, and cell growth regulation. Here, we aimed to assess the potential influence of the IL-6 single nucleotide polymorphism (SNP) rs1800796 on the concentration/dose (C/D) ratios of tacrolimus and donor liver function in Chinese liver transplant patients. A total of 331 liver transplant patients were included in this study. The C/D ratios and the ALT, AST, T-BIL, ALP, and GGT levels were analyzed at different time points in patients with and without the IL-6 rs1800796 SNP. The IL-6 rs1800796 polymorphism in recipients was found to be correlated with the C/D ratios of tacrolimus at months 2 to month 6 after transplantation. Also, the rs1800796 SNP in donors was found to influence liver function (shown in the data of ALT, AST, T-BIL, ALP and GGT) in recipients at the early post-transplant stage after transplantation. In conclusion, the IL-6 rs1800796 polymorphism was associated with the C/D ratios of tacrolimus and post-transplant donor liver function.

KEYWORDS:

• IL-6 single nucleotide polymorphism
• tacrolimus concentration/dose ratios
• liver transplantation

Author’s contributions

Feng Wang and FeiliWei designed the experiment and wrote the manuscript. Dexi Chen and Yunjin Zang assisted in designing the experiment and provided fund support. Huan Liu, Xin Wang, Wenjing Wang, Yabo Ouyang and Jianyu Liu collected and analyzed the data.

Disclosure statement

The authors report no conflict of interest.

Additional information

Funding

This work was funded in part by the NSFC [No.81701582], “Clinical medicine+X” Foundation of the Medical Department of Qingdao University [2017224], and Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Provice [CXPJJH11800001-2018320].