COVID-19 Infection: Concise Review Based on the Immunological Perspective

ABSTRACT

The outbreak of coronavirus disease 2019 (COVID-19) has posed a serious threat to public health. There is an urgent need for discovery methods for the prevention and treatment of COVID-19 infection. Understanding immunogenicity together with immune responses are expected to provide further information about this virus. We hope that this narrative review article may create new insights for researchers to take great strides toward designing vaccines and novel therapies in the near future. The functional properties of the immune system in COVID-19 infection is not exactly clarified yet. This is compounded by the many gaps in our understanding of the SARS-CoV-2 immunogenicity properties. Possible immune responses according to current literature are discussed as the first line of defense and acquired immunity. Here, we focus on proposed modern preventive immunotherapy methods in COVID-19 infection.

KEYWORDS:

• Coronavirus
• 2019 novel coronavirus
• COVID-19
• host immune response
• vaccine development

Acknowledgments

The authors would like to thank the staff of the Immunology Research Center of Tabriz University of Medical Sciences for the sincere collaboration and support.

Disclosure statement

The authors declare that there is no conflict of interest.

Data Availability Statement

Data sharing not applicable to this article as no datasets were generated or analysed during the current study. https://ind01.safelinks.protection.outlook.com/?url=https:%2F%2Fauthorservices.taylorandfrancis.com%2Fdata-sharing-policies%2Fdata-availability-statements%2F%23:~:text%3DAs%2520a%2520data%2520availability%2520statement%2Canonymized%2520version%2520of%2520the%2520manuscript.%26text%3DThe%2520data%2520that%2520support%2520the%2Creference%2520number%2520%255Breference%2520number%255D&data=02%7C01%7Csathyan.dhanasekaran%40integra.co.in%7Ca61cc99bb6194ceccbb008d85f9ee080%7C70e2bc386b4b43a19821a49c0a744f3d%7C0%7C0%7C637364483269538189&sdata=n%2FbXrm4%2BFzCCjf1hxEMWLMkx3j5WOzq5loZbu1WELQ8%3D&reserved=0

Additional information

Funding

This study received no specific grant from any funding bodies.