ABSTRACT
Aim
The aim of the study was to evaluate the association of IL‐18 137 G > C, 607 C > A gene polymorphism in Uyghur population with chronic periodontitis (CP) and combine the results with the meta-analysis
Methods
In a case‐control study, 200 cases with CP and 100 healthy controls were recruited; IL‐18 137 G > C, 607 C > A genotyping was performed by polymerase chain reaction‐restriction fragment length polymorphism (PCR-RFLP). In the meta‐analysis, we used electronic databases, including CNKI, Wan Fang, PubMed, EMBASE databases etc.to obtain relevant research published through June 2020. Studies were considered eligible if odds ratios (ORs) and 95% confidence intervals (95% CI) were provided or calculated from the given data. The size of the combined effect was calculated using STATA 15.0
Results
Our study revealed significant association between CP and IL‐18 137 G > C (P = .045, OR = 1.67), 607 C > A (P = .045, OR = 1.67). The overall meta‐analysis revealed significant associations between IL‐18 137 G > C polymorphism and CP risk in Allele, dominant, co-dominant and recessive genetic models. The subgroup analysis also showed a significant association between the IL‐18 137 G > C and risk for periodontitis and aggressive periodontitis in the Asian (GC+ CC VS. GG: P = .047, OR = 1.64,95%CI = 1.01–2.68)
Conclusions
IL‐18 137 G > C, 607 C > A could be associated with susceptibility to periodontitis in Uyghur population. Further case-control of candidate genes studies targeting larger sample sizes and different ethnic groups are needed to arrive more accurate conclusions.
Acknowledgment
In addition, the authors specifically acknowledge the guidance and insightful ideas provided by Professor Zhao Jin
Disclosure statement
The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.
Data availability statement
All data generated or analyzed during this study are included in this article.