Optical Biometry Derived Axial Length Measurements Following Intravitreal Anti-Vascular Endothelial Growth Factor Treatment for Macular Edema

ABSTRACT

Purpose: To evaluate axial length (AL) alterations in patients with macular disease over the course of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods: In this prospective, comparative study, 33 patients with macular edema underwent unilaterally intravitreal anti-VEGF therapy and were followed for two months; the contralateral eyes were considered as controls. Central retinal thickness (CRT) was measured with spectral-domain optical coherence tomography and AL with an IOL-Master optical biometer. Results: CRT of the treated eyes decreased by 35.33 ± 65.59 μm (range, –222.00–67 μm), while AL increased by 0.008 ± 0.062 mm (range, –0.11–0.18 mm). CRT of the control group decreased by 9.82 ± 65.40 μm (range, –203–182 μm), and AL increased by 0.011 ± 0.129 mm (range, –0.20–0.67 mm). No significant correlation was detected between CRT and AL parameters (rhos=0.026, P=0.882). Conclusions: Anti-VEGF administration has no significant impact on optical biometry-derived AL measurements.

Keywords:

• Anti-vascular endothelial growth factor
• axial length
• central retinal thickness
• IOL Master biometry
• macular edema

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.