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International Reviews of Immunology Volume 23, 2004 - Issue 5-6
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Research Article

APPLICATION OF VIP/NTM-REACTIVE NATURAL ANTIBODIES IN THERAPY OF HIV DISEASE

VELJKO VELJKOVIC Center for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, Belgrade, YugoslaviaCorrespondence[email protected]
&
RADMILA METLAS Diapharm Ltd., St. Peterport, Guernsey, Channel Islands, UK
Pages 437-445 | Published online: 03 Aug 2009
 
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Abstract

In sera of HIV-infected individuals natural antibodies recognizing nonimmunogenic C-terminal domain of the second conserved region of HIV-1 gp120 and the vasoactive intestinal peptide (VIP) were identified. It has been demonstrated that these antibodies are significantly more prevalent in asymptomatic carriers than in AIDS patients and that their titer strongly correlates with disease progression. These findings point out the VIP/C2-reactive natural antibodies as an important agent for immunotherapy of HIV disease.

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