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International Reviews of Immunology Volume 23, 2004 - Issue 5-6
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Research Article

STRUCTURED THERAPY INTERRUPTION (STI) AND DECEPTIVE IMPRINTING

HEINZ KOHLER ImmPheron Inc., Lexington, Kentucky, USACorrespondence[email protected]
Pages 455-463 | Published online: 03 Aug 2009
 
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Abstract

The immune response in individuals chronically infected with HIV-1 is unable to prevent progression of disease. Diversion of immune recognition via ‘Deceptive Imprinting’ allows virus variants to continue the infection. Stuctured Interrupting of (HAART) therapy (STI) causes rebound of virus with ‘wild-type’ strains that stimulate the immune system. Combining STI with suppression of the dominant response against anti-wild–type virus is proposed to enhance the beneficial effects of STI.

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