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International Reviews of Immunology Volume 26, 2007 - Issue 1-2
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Regulation of Type 1 Diabetes by NKT Cells

Jan Novak INSERM U561, Université René Descartes, Hôpital Cochin/Saint Vincent de Paul, Paris, France
,
Thibault Griseri INSERM U561, Université René Descartes, Hôpital Cochin/Saint Vincent de Paul, Paris, France
,
Lucie Beaudoin INSERM U561, Université René Descartes, Hôpital Cochin/Saint Vincent de Paul, Paris, France
&
Agnès Lehuen INSERM U561, Université René Descartes, Hôpital Cochin/Saint Vincent de Paul, Paris, FranceCorrespondence[email protected]
Pages 49-72 | Published online: 03 Aug 2009
 
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Abstract

Type 1 diabetes is an autoimmune disease due to the destruction of insulin-producing pancreatic β cells. Natural Killer T (NKT) cells are a T-cell subset that links the innate and adaptive immune systems. NKT cells play a key regulatory role in type 1 diabetes. The absence of NKT cells correlates with exacerbation of type 1 diabetes, whereas an increased frequency and/or activation of NKT cells prevents β-cell autoimmunity. Various mechanisms are involved in the protective effect of NKT cells. The goal is now to translate knowledge gained from mouse models into human therapeutics.

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