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ABSTRACT
In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, including hematogenous metastasis, lymphatic metastasis, local invasion and transcoelomic metastasis, to summarize the roles and underlying mechanisms of IL-17A on tumor metastasis.
Acknowledgment
The authors are grateful for the support by the Project of Tianjin Natural Science Foundation (15JCYBJC26000 to W.M.D), National Natural Science Foundation of China (no. 81501887 to Z.J.L) and the Great Programme for Science and Technology in Logistics College of Chinese People's Armed Police Forces (WHB201610 to N.X.L).
Declaration of interest
The authors declare that they have no conflict of interest.