Reg3β: A Potential Therapeutic Target for Tissue Injury and Inflammation-Associated Disorders

Abstract

Since regenerating islet-derived 3β (Reg3β) was first reported, various studies have been conducted to explore the involvement of Reg3β in a gamut of maladies, such as diabetes, pancreatitis, pancreatic ductal adenocarcinoma, and extrapancreatic maladies such as inflammatory bowel disease, acute liver failure, and myocardial infarction. Surprisingly, there is currently no systematic review of Reg3β. Therefore, we summarize the structural characteristics, transcriptional regulation, putative receptors, and signaling pathways of Reg3β. The exact functional roles in various diseases, especially gastrointestinal and liver diseases, are also discussed. Reg3β plays multiple roles in promoting proliferation, inducing differentiation, preventing apoptosis, and resisting bacteria. The present review may provide new directions for the diagnosis and treatment of gastrointestinal, liver, and pancreatic diseases.

Keywords:

• Bactericidal agent
• liver generation
• myocardial infarction
• pancreas
• Reg3β

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81671567, 81871244, and 81771756), Jiangsu Province “333” project (BRA2018016), Social Development Foundation of Jiangsu Province (BE2019700), Six Talent Peaks Project in Jiangsu Province (2019-WSN-122), and the Social Development Foundation of Zhenjiang (SH2019076).