Association between TNF-α and IFN-γ levels and severity of acute viral bronchiolitis

Abstract

Acute bronchiolitis caused by the respiratory syncytial virus triggers an inflammatory response with the production and release of several pro-inflammatory cytokines. Evidence suggests that their levels are associated with the severity of the infection. This systematic review and meta-analysis aim to assess whether the levels of TNF-α and IFN-γ are associated with the severity of acute viral bronchiolitis. We searched MEDLINE libraries (via PUBMED), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Scientific Electronic Library Online (SciELO), Latin American Caribbean Health Sciences Literature (LILACS), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and the gray literature through April 2020. Random effect models were used for general and subgroup analysis. In total, six studies were included with a total of 744 participants. The mean TNF-α levels between the severe group did not differ from the control group 0.14 (95% CI: −0.53 to 0.82, I² = 91%, p < 0.01); the heterogeneity was high. The results remained insignificant when the analyses were performed including only studies with high quality 0.25 (95% CI: −0.46 to 0.96, I² = 92%, p < 0.01) I² = 95%, p = 0.815), when TNF-α was nasal 0.60 (95% CI: −0.49 to 1.69), I² = 94%, p < 0.01), or serum −0.08 (95% CI: −0.48 to 0.31), I² = 29%, p = 0.24). In the analysis of studies measuring IFN-γ, there was also no significance of −0.67 (95% CI: −1.56 to 0.22, I² = 76%, p = 0.04). In conclusion, this meta-analysis suggests that the most severe patients do not have different mean TNF-α and IFN-γ values ​than patients with mild disease, but the heterogeneity of the studies was high.

Supplemental data for this article is available online at https://doi.org/10.1080/08830185.2021.1889534.

Keywords:

• Acute viral bronchiolitis
• interferon range
• respiratory syncytial virus
• alpha tumor necrosis factor

Acknowledgments

We acknowledge Fundação de Amparo à Pesquisa do Rio Grande do Sul (FAPERGS), the National Research Council of Brazil (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES Finance Code 001.

Declaration of Interest

The authors have nothing to disclose.