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CRANIO®
The Journal of Craniomandibular & Sleep Practice
Volume 39, 2021 - Issue 3
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TMJ

Evaluation of serum prolidase activity and oxidative stress in patients with temporomandibular joint internal derangement

, DDS, PhDORCID Icon, , DDS, MDS, , DDS, PhD, , DDS, PhDORCID Icon & , DDS, PhD
Pages 238-248 | Published online: 25 Apr 2019
 

ABSTRACT

Objective: To investigate serum prolidase activity and oxidative stress in patients with temporomandibular joint internal derangement (TMJ-ID).

Methods: Seventy patients with Wilkes stage III, IV, and V joints and 70 healthy controls were included. Serum prolidase activity and oxidative stress parameters, including total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), advanced oxidation protein products (AOPP), glutathione (GSH), ferric reducing antioxidant power (FRAP), and lipid hydroperoxide (LOOH) were measured.

Results: The levels of prolidase, TOS, OSI, AOPP, and LOOH were significantly higher in the TMJ-ID group than in the control (p = .0001). TAS and FRAP level was significantly lower in the TMJ-ID group than in the control (p = .0001). There was no significant difference in GSH between groups.

Conclusion: Significantly increased prolidase activity and oxidative stress in patients with TMJ-ID may be related to long-term collagen tissue damage, and inflammation and can be effective in the etiology of TMJ-ID.

Disclosure of interest

The authors report no conflicts of interest.

Additional information

Funding

No source of funding was used in this study.

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