The association of T102C (rs6313) polymorphism in the 5-HT2A receptor gene with temporomandibular disorders and anxiety in a group of Turkish population

ABSTRACT

Objective

To investigate the relationship between T102C (rs6313) polymorphism in the 5-hydroxytryptamine receptor-2A (5HTR2A) gene and temporomandibular disorder (TMD) and anxiety.

Methods

This observational case-control study included 80 patients and 70 healthy controls. TMD was diagnosed using the criteria for TMD (DC/TMD). Anxiety was assessed with the Beck anxiety scale. A genotyping study of HTRR2A T102C (rs6313) gene polymorphism was performed from genomic DNA isolated from blood.

Results

The TMD group had higher anxiety scores than the control group (p < .05). The TMD group was similar to the control group regarding genotype and allele frequencies. However, the polymorphic CC genotype was more common in those with high anxiety (p < .05).

Conclusion

There was no clear evidence of an association between TMD and the T102C polymorphism in HTR2A and TMD. However, anxiety is closely related to the T102C polymorphism in HTR2A.

KEYWORDS:

• Anxiety
• serotonin(5-HT)
• 5-hydroxytryptamine-receptor-2A(5-HTR-2A)
• T102C polymorphism
• temporomandibular disorder

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors’ contributions

Ömer Ekici: Conceptualization, project administration, supervision, investigation, methodology, data curation, formal analysis, software, writing – original draft.

Evrim Suna Arıkan Söylemez: Methodology, supervision, data curation, formal analysis writing – review & editing.

Consent for publication

The manuscript has been read and approved by the authors. Authors are responsible for correctness of the statements provided in the manuscript. Author allow this study to be published in the CRANIO: The Journal of Craniomandibular & Sleep Practice. The manuscript has not been published in any form or any language and is only submitted to the CRANIO: The Journal of Craniomandibular & Sleep Practice.

Ethics statement/confirmation of patient permission

This study was approved by Afyonkarahisar Health Sciences University, Clinical Research Ethics Committee (decision dated September 2 2022 and numbered 11 − 453). This study was carried out in full compliance with the principles of the Declaration of Helsinki.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.