No genetic association between sleep traits and periodontitis: A bidirectional two-sample Mendelian randomization study

ABSTRACT

Objective

This study aimed to investigate the potential genetic link between sleep traits and periodontitis.

Methods

A two-sample bidirectional Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association studies data on chronotype, daytime sleepiness, daytime napping frequency, insomnia, sleep duration, snoring, and the apnea-hypopnea index (AHI), along with a separate dataset on periodontitis.

Results

Chronotype (OR = 0.929, 95% CI = 0.788–1.095), daytime sleepiness (OR = 0.492, 95% CI = 0.186–1.306), daytime napping frequency (OR = 1.178, 95% CI = 0.745–1.863), sleep duration (OR = 0.868, 95% CI = 0.644–1.169), AHI (OR = 1.124, 95% CI = 0.980–1.289), insomnia (OR = 0.832, 95% CI = 0.440–1.573), and snoring (OR = 0.641, 95% CI = 0.198–2.075) had no effect on periodontitis. Similarly, periodontitis demonstrated no significant effect on sleep traits.

Conclusions

There is no evidence of a bidirectional genetic relationship between sleep traits and the risk of periodontitis.

KEYWORDS:

• Periodontitis
• Mendelian randomization analysis
• sleep
• sleep disorders

Acknowledgments

The authors thank and acknowledge the investigators of the original GWAS studies for publishing summary data used in the study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

All data generated or analyzed during this study are included in supplementary material or in the data repositories listed in the methods.

Authors’ contributions

Conception and design: Xin Chen and Zhibai Zhao. Methodology: Zheng Cheng and Junyu Xu. Data acquisition: Qianyi Wang. Data analysis and interpretation: Xin Chen and Zheng Cheng. Writing of article: Xin Chen and Qianyi Wang. Review of article: Zhibai Zhao and Qianglin Jiang.

Ethics approval

The present MR study was based on the previously collected and published data, no ethics approval was required.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/08869634.2024.2384681

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.