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Abstract
Much emphasis has been placed on the so-called “biologics” in the treatment of immune disorders within the last few years. Here we discuss the expanding horizon of potential strategies for immunotherapies targeting T lymphocytes as key effectors and regulators of autoimmunity. We review emerging reagents in a variety of animal models and human disorders that may offer new therapeutic options in current or modified iterations.
| Abbreviations | ||
| ACR | = | American College of Rheumatology |
| ADCC | = | Antibody dependent cellular cytotoxicity |
| APL | = | Altered peptide ligand |
| CIA | = | Collagen-induced arthritis |
| CRS | = | Cytokine release syndrome |
| DTH | = | Delayed type hypersensitivity |
| EAE | = | Experimental autoimmune encephalitis |
| EDSS | = | Extended disability status scale |
| GVHD | = | Graft versus host disease |
| HLA | = | Human leukocyte antigen |
| IDDM | = | Insulin dependent diabetes mellitus |
| IFN-γ | = | Interferon gamma |
| LFA | = | Lymphocyte function-associated antigen |
| mAb | = | Monoclonal antibody |
| MBP | = | Myelin basic protein |
| MHC | = | Major histocompatibility complex |
| MS | = | Multiple sclerosis |
| MTX | = | Methotrexate |
| PASI | = | Psoriasis area and severity index |
| PsAr | = | Psoriatic Arthritis |
| PV | = | Pemphigus vulgaris |
| RA | = | Rheumatoid arthritis |
| RCT | = | Randomized clinical trial |
| SLE | = | Systemic lupus erythematosis |
| TCR | = | T cell receptor |
| TCV | = | T cell vaccine |
| TID | = | Type I diabetes |
| TNF | = | Tumor necrosis factor |
| UC | = | Ulcerative colitis |
| Abbreviations | ||
| ACR | = | American College of Rheumatology |
| ADCC | = | Antibody dependent cellular cytotoxicity |
| APL | = | Altered peptide ligand |
| CIA | = | Collagen-induced arthritis |
| CRS | = | Cytokine release syndrome |
| DTH | = | Delayed type hypersensitivity |
| EAE | = | Experimental autoimmune encephalitis |
| EDSS | = | Extended disability status scale |
| GVHD | = | Graft versus host disease |
| HLA | = | Human leukocyte antigen |
| IDDM | = | Insulin dependent diabetes mellitus |
| IFN-γ | = | Interferon gamma |
| LFA | = | Lymphocyte function-associated antigen |
| mAb | = | Monoclonal antibody |
| MBP | = | Myelin basic protein |
| MHC | = | Major histocompatibility complex |
| MS | = | Multiple sclerosis |
| MTX | = | Methotrexate |
| PASI | = | Psoriasis area and severity index |
| PsAr | = | Psoriatic Arthritis |
| PV | = | Pemphigus vulgaris |
| RA | = | Rheumatoid arthritis |
| RCT | = | Randomized clinical trial |
| SLE | = | Systemic lupus erythematosis |
| TCR | = | T cell receptor |
| TCV | = | T cell vaccine |
| TID | = | Type I diabetes |
| TNF | = | Tumor necrosis factor |
| UC | = | Ulcerative colitis |