PRED^NOD, a prediction server for peptide binding to the H-2^g7 haplotype of the non-obese diabetic mouse

Abstract

The non-obese diabetic (NOD) mouse is a widely used animal model for study of autoimmune diseases, in particular human type 1 diabetes mellitus (T1DM). Identification of the subset of peptides that bind MHC molecules comprising the H-2^g7 haplotype of NOD mouse and thereby representing potential NOD T-cell epitopes is important for research into the pathogenesis and immunotherapy of T1DM. The H-2^g7 haplotype comprises the MHC class-I molecules K^d and D^b and a single class-II molecule I-A^g7. We have developed a prediction system, PRED^NOD, for accurate identification of peptides that bind the MHC molecules constituting the H-2^g7 haplotype. PRED^NOD is accessible at http://antigen.i2r.a-star.edu.sg/Ag7.

• Autoimmune diabetes
• I-A^g7 haplotype
• NOD
• type 1 diabetes