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Autoimmunity Volume 40, 2007 - Issue 1
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Original

Down-regulation of CD72 and increased surface IgG on B cells in patients with lupus nephritis

Souichiro Nakano Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Shinji Morimoto Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Jun Suzuki Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Akiko Mitsuo Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Yutaka Nakiri Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Akira Katagiri Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Kazuhisa Nozawa Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Hirofumi Amano Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Yoshiaki Tokano Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
,
Hiroshi Hashimoto Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
&
Yoshinari Takasaki Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, 113-8421, Japan
 show all
Pages 9-15 | Received 16 May 2006, Accepted 13 Nov 2006, Published online: 07 Jul 2009
 
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Abstract

The significance of both the acceleratory and inhibitory functions of the CD72 molecule was investigated among patients with systemic lupus erythematosus (SLE) during modification of B cell differentiation. Expression of the CD72 molecule and mRNA on B cells was decreased in SLE with lupus nephritis, while CD100 expression on both CD4+ T cells and CD8+ T cells was not significant in comparison with the controls. When the relationship between CD72 expression and other B cell markers was examined, decreased expression of CD72 was associated with differences in the stage of differentiation. In patients with decreased expression of CD72, switching to IgG was evident, and the disease stage was started to severe. In patients with lupus nephritis, the decreased expression of CD72 was related to class switching on B cells, suggesting that CD72 is a useful marker for determining class switching of B cells in lupus nephritis.

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