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Autoimmunity Volume 40, 2007 - Issue 1
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Original

Gene expression profiles reveal homeostatic dynamics during interferon-β therapy in multiple sclerosis

Viviana Annibali Department of Neurology and Center for Experimental Neurological Therapy, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
,
Simone Di Giovanni Department of Neurology and Center for Experimental Neurological Therapy, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
,
Stefania Cannoni Department of Neurology and Center for Experimental Neurological Therapy, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
,
Elisabetta Giugni Neuroradiology, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
,
Roberto Bomprezzi Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD20892, USA
,
Carlo Mattei Department of Neurology and Center for Experimental Neurological Therapy, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
,
Abdel Elkahloun Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD20892, USA
,
Eliana Marina Coccia Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy
,
Marco Alfò Department of Statistics, Probability and Applied Statistics, University of Rome “La Sapienza”, Rome, Italy
,
Francesco Orzi Department of Neurology and Center for Experimental Neurological Therapy, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
,
Giovanni Ristori Department of Neurology and Center for Experimental Neurological Therapy, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
&
Marco Salvetti Department of Neurology and Center for Experimental Neurological Therapy, S. Andrea Hospital, University of Rome “La Sapienza”, Rome, Italy
 show all
Pages 16-22 | Received 20 Sep 2006, Accepted 22 Nov 2006, Published online: 07 Jul 2009
 
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Abstract

Understanding the mechanisms that sustain the effects of disease modifying drugs in multiple sclerosis (MS) may help refine current therapies and improve our knowledge of disease pathogenesis.

By using cDNA microarrays, we investigated gene expression in the peripheral blood mononuclear cells (PBMC) of 7 MS patients, at baseline (T0) as well as after 1 (T1) and 3 months (T3) of interferon beta-1a (IFN-β-1a; Rebif™ 44 μg) therapy.

Gene expression changes involved genes of both immunological and non-immunological significance. We validated IL-10 up-regulation, which is in accordance with previous reports, and other novel changes that underscore the capacity of IFN-β to impair antigen presentation and migration of inflammatory elements into the central nervous system (up-regulation of filamin B and down-regulation of IL-16 and rab7).

Overall, gene expression changes became less pronounced after 3 months of therapy, suggesting a homeostatic response to IFN-β. This may be of use for the design of new treatment schedules.

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