Advanced search
Publication Cover
Autoimmunity Volume 40, 2007 - Issue 4
Submit an article Journal homepage
172
Views
34
CrossRef citations to date
0
Altmetric
Original

Clearance of dying cells and autoimmunity

Review

Sylwia Michlewska The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK
,
Aisleen McColl The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK
,
Adriano G Rossi The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK
,
Ian L Megson UHI Millennium Institute, The Green House, Beechwood Business Park North, Inverness, IV2 3BL, Scotland, UK
&
Ian Dransfield The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK
Pages 267-273 | Published online: 07 Jul 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.

Acknowledgements

The Funding support of the Wellcome Trust and the Medical Research Council is gratefully acknowledged.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later
PDF download + Online access
  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart
* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.