Antifouling terpenes and steroids against barnacle larvae from marine sponges

Six terpenoids and two steroids have been isolated from three marine sponges as antifoulants, viz. manoalide (1), seco‐manoalide (2), manoalide 25‐acetate (3), (4E,6E)‐dehydromanoalide (4) from Smenospongia sp., (+)‐curcuphenol (5) and (+)‐curcudiol (6) from Myrmekioderma dendyi, and tri‐2‐aminoimidazolium halistanol sulfate (7) and halistanol sulfate (8) from Topsentia sp. These compounds showed antifouling activity but not toxicity against cypris larvae of the barnacle Balamis amphitrite, with EC_S0 values of 0.24, 0.80, 0.53, 2.7, 2.5, 2.8, 4.0, and 2.9 μgml^‐1 respectively.

Key words:

• antifoulants
• barnacle
• marine sponge
• Topsentia sp.
• Smenospongia sp.
• Myrmekioderma dendyi

Notes

Present address: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo‐ku, Tokyo 113, Japan

Present address: Kawachi Millibioflight Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), 4–7–6 Komaba, Meguro‐ku, Tokyo, Japan

Corresponding author; fax: [phone]; e‐mail: [email protected]‐tokyo.ac.jp

Additional information

Notes on contributors

Nobuhiro Fusetani

† *