Application of magnetic electrospun polyvinyl alcohol/collagen nanofibres for drug delivery systems

ABSTRACT

A magnetic electrospun nanofibre was prepared and applied to load and release bovine serum albumin (BSA). Fe₃O₄ magnetic nanoparticles were prepared by chemical co-precipitation of ferric and ferrous salts and coated with polyvinyl alcohol/collagen electrospun nanofibre. Tripolyphosphate (TPP) and glutaraldehyde were used to stabilise nanoparticles within the electrospun nanofibres. It was found from scanning electron microscopy graphs that TPP is more suitable than glutaraldehyde and a network of relatively tall and perfectly uniform fibres with smooth surface can be produced and magnetic nanoparticles in their smallest size are distributed all over the fibres network without any agglomeration. BSA protein was loaded in magnetic nanofibres and its releasing under magnetic field and in the absence of magnetic field was studied using the Bradford assay method. The magnetic nanofibres completely changed the structure and formed pores and cracks under the magnetic field and then released BSA after 3 h, about 12 times higher than its releasing in the absence of magnetic field.

KEYWORDS:

• Electrospinning
• collagen
• polyvinyl alcohol
• magnetic nanoparticle

Disclosure statement

No potential conflict of interest was reported by the author(s).