Molecular Dynamics of Poly(Lactide-Co-Glycolide) Controlled Pharmaceutical Release Polymers: Preliminary Solid State NMR

Abstract

Variable temperature ¹³C cross polarization magic angle spinning (CP-MAS) and ¹H T ₁ and T _1p studies have been initiated on microspheres of the poly(lactide-co-glycolide) (PLGA) materials widely studied as controlled release pharmaceutical formulation excipients. Temperature dependence of lineshape and T _1p suggest that around the broad glass transition at about 50°C slow polymer backbone motions (on the 10 to 100 μs time scale) become significant; modelling of these is in progress.

Key Words:

• Controlled release
• poly(lactide-co-glycolide)
• PLGA
• solid state NMR