Clinical Significance of Endothelin-1 And C Reaction Protein in Restenosis After the Intervention of Lower Extremity Arteriosclerosis Obliterans

Abstract

Objective

This study aims to investigate the role of endothelin-1 (ET-1) and C-reactive protein (CRP) in restenosis after intervention of lower extremity arteriosclerosis obliterans.

Methods

The present prospective observational study included a total of 251 patients with arteriosclerosis obliterans in the lower extremity. All patients were treated with balloon dilatation, stent-assisted angioplasty or balloon dilatation, and stent-assisted angioplasty. Furthermore, these patients received a CTA examination at one and three months after surgery. The serum ET-1 and CRP levels were determined using a commercial enzyme-linked immunosorbent assay (ELISA).

Results

In non-restenosis patients, both the CRP and ET-1 levels were significantly upregulated after surgery, reached a peak level at one week, and decreased at one month after surgery. However, for restenosis patients, the serum ET-1 and CRP levels did not decrease to the baseline at one and three months after surgery, but were remarkably higher than the levels for non-restenosis patients. Serum ET-1 levels were positively correlated with serum CRP levels at both one and three months after surgery. Both ET-1 and CRP levels after one week and one month, and CRP at three days, one week, one month and three months after surgery were risk factors for restenosis after intervention surgery of arteriosclerosis obliterans.

Conclusion

Both serum ET-1 and CRP levels were elevated after one and three months of intervention for lower extremity arteriosclerosis obliterans in patients with restenosis. These might be the risk factors for restenosis of lower extremity arteriosclerosis obliterans patients.

Keywords:

• Endothelin-1
• C-reactive protein
• Restenosis
• Arteriosclerosis obliterans

Acknowledgements

This work is support by the Chongming Branch of Tenth People’s Hospital of Tongji University.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author’s contribution

Each author has made an important scientific contribution to the study and has assisted with the drafting or revising of the manuscript.

Ethics, consent and permissions

A written informed consent was obtained from all patients. The present study was approved by the Ethics Committee of the Chongming Branch of Tenth People’s Hospital of Tongji University.

Consent to publish

All of the authors have Consented to publish this research.

Additional information

Funding

This study was funded by the Outstanding Young and Middle-aged Scientists in Shandong Province (SQ20160033).