Abstract
Background
Perioperative neurocognitive disorders (PND) resulting from cardiac surgery is a complication with high morbidity and mortality. However, the pathogenesis is unknown.
Methods
For the sake of investigating the risk factors and mechanism of PND, we collected the characteristics and neurological scores of patients undergoing cardiac surgery in the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University and Affiliated Hospital of Southwest Medical University from Jan 1, 2016 to Dec 11, 2018.
Results
We found that age and left atrial thrombus are independent risk factors for PND after cardiac surgery. Furthermore, the serum of 29 patients was collected on the 7th day after cardiac surgery for detecting the expression of lncRNA-MYL2-2 and miR-124-3p. Increased lncRNA-MYL2-2 and decreased miR-124-3p in serum were associated with the decline of patients’ cognition.
Conclusions
LncRNA-MYL2-2 and miRNA-124-3p may jointly participate in the occurrence and development of PND after cardiac surgery. These important findings are advantaged to further understand the pathogenesis of PND and prevent it, provide new biomarkers for the diagnosis and monitoring of PND.
Acknowledgments
The authors want to thank all the participants who involve in this study.
Statement of ethics
The research was conducted ethically in accordance with the ethical guideline. All subjects have given their written informed consent and that the study protocol was approved by the committee on human research.
Disclosure statement
The authors have no conflicts of interest to declare.
Author contributions
FXY and YZ participated in the experimental conception and design; QXX, CXC, and RD performed the experiments; RD, LQ, RYB, and HL performed the data collection and analysis. QXX and CXC wrote the initial manuscript and YZ revised the article. All the authors contributed to the draft and read the article as well as approved the final version.