Bacteria Associated with Granulomatous Lobular Mastitis and the Potential for Personalized Therapy

Abstract

Granulomatous lobular mastitis (GLM), also known as idiopathic granulomatous mastitis (IGM), is a chronic inflammatory lesion of the breast. The incidence of GLM has been increasing in recent years, especially among young women. The etiologies of GLM have not been fully elucidated but are associated with autoimmunity and bacterial infection. Bacteria, especially Corynebacterium species, play important roles in GLM. In this article, we review research progress regarding the bacteriology of GLM attained with the application of several new high-throughput detection techniques. Accurate detection might be important for deepening our understanding of the pathogenesis of GLM and hold promise for personalized GLM therapy.

KEYWORDS:

• Granulomatous lobular mastitis
• bacteriology
• corynebacterium species
• gene sequencing
• personalized therapy

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Author contributions

All authors contributed equally to this manuscript.

Additional information

Funding

This work was supported by the Fundamental Research Funds for the Central Universities [2042019kf0229], the Natural Science Foundation of Hubei Province, China [2016CFB331], Medical Science Advancement Program (Clinical Medicine) of Wuhan University [TFLC2018002], and National Key Research and Development Program [2018YFA0900400].