Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis

Abstract

Autologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured by ELISA. All patients showed significant improvements in pain and function following treatment of KOA with PL and PRP compared to baseline. Moreover, PL's concentration of growth factors was significantly higher than PRP. A significant increase was also observed in all of the aforementioned mediators in both PRP and PL products compared to control. These results can introduce PL as a promising and alternative option for KOA therapy in the future.

Keywords:

• Knee osteoarthritis
• platelet-rich plasma
• platelet lysate
• KOA therapy

Acknowledgment

The authors are grateful of the participants for their contribution in accomplishing this study and Noavaran Salamat Arzhang Co. for donating Standard PRP and Platelet lysate preparation kits. The financial support of this study was underwritten by a grant from Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Science, Tabriz, Iran (grant number: 61972).

Ethical approval and consent to participate

This study approved by the Research Ethics Committee of Tabriz University of Medical Science (No: IR.TBZMED.REC.1397.923) and registered in the Iranian Registry of Clinical Trial Database (IRCT20160422027520N10). Written informed consent was obtained from all participants after receiving an explanation of the study.

Consent for publication

All authors read and approved the final manuscript for publication.

Author contributions

SKS, AP, and MY contributed to the conception and design of the study. SH, MS S-Z, MZ, and YY performed the laboratory assays. RR and RM contributed to sample collection. MS S-Z performed the statistical analysis. SH and MS S-Z wrote the manuscript. AG and RI contributed to the acquisition of data. RM and AM contributed to editing the final version of the manuscript. All authors reviewed the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data cannot be shared in public because of ethics and individual privacy restrictions but are limitedly available by contacting the corresponding author of this study, privately.

Additional information

Funding

The financial support of this study was underwritten by a grant from Physical Medicine and Rehabilitation Research Centre, Tabriz University of Medical Science, Tabriz, Iran [grant number: 61972].