Comparative effects of 8-week combined resistance exercise training and alternate-day calorie restriction on soluble epidermal growth factor receptor (sEGFR) and adipsin in obese men

Abstract

This study investigated the combined effects of resistance exercise training (RET) and alternate-day calorie restriction (ADCR) on body composition, insulin resistance (IR), insulin resistance-related biomarkers (adipokine adipsin and hepatokine soluble EFGR), and weight loss in obese men. The findings revealed that RET + ADCR induced the greatest reductions in body weight, body fat percentage, and waist-to-hip ratio (WHR) compared to RET and ADCR alone (p < 0.05). Additionally, RET + ADCR resulted in the most significant improvements in IR, as measured by HOMA-IR, and in circulating levels of adipsin and soluble EFGR (p < 0.05). These findings suggest that combining RET and ADCR may be a more effective strategy for improving metabolic health, including body composition, IR, and metabolic tissues’ functions, in obese men than either intervention alone.

Keywords:

• Resistance exercise training (RET)
• alternate-day calorie restriction (ADCR)
• adipsin
• soluble EFGR
• body composition
• insulin resistance (IR)

Acknowledgments

The authors wish to thank the participants and hospital staff for their sincere cooperation throughout the study. Further acknowledgment goes to Dr. Safarzade, the supervisor of the study, for his comprehensive guidelines.

Authors contributions

YH: study design and data collection; AS: study concept and design; HA: analysis and interpretation of results and manuscript preparation. All the authors reviewed and approved the manuscript for submission.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data Availability Statement

Data will be made available upon request.

Additional information

Funding

The study received no funding.