Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

Abstract

This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.

Keywords:

• Complement system
• complement inhibitor
• drug delivery
• hypersensitivity
• immunogenicity
• liposome
• macrophage

Acknowledgments

Financial support by the Danish Agency for Science, Technology and Innovation (Det Strategiske Forskningsråd; reference 2106-08-0081) and the National Office for Research and Technology (NKTH), Budapest (NAP-NANO and CAPRA777) are gratefully acknowledged.

Declaration of interest: The authors report no financial conflicts of interest. The authors alone are responsible for the content and writing of this paper.