Advanced lipid technology

Abstract

Phospholipids and cholesterols are being spotlighted as raw materials for preparing liposomes, one of the key compounds for drug delivery systems (DDS), and as base compounds for converting water-soluble drugs to fat-soluble drugs. Other applications of phospholipids also are being explored. Nippon Fine Chemical, aware of the future of such lipids, has developed new processes for synthesizing and purifying phospholipids and is supplying them on an industrial scale. These products – used worldwide – are highly regarded as raw materials for preparing liposomes. In particular, Nippon Fine Chemical’s innovative research led to the development of “Presome®”, a base agent that facilitates the preparation of liposome solutions. To further this research, Nippon Fine Chemical has established an “Advanced Lipid Technology”.

Keywords:

• Anti-angeogenic therapy
• high-purity phospholipids and cholesterols
• long circulation
• Presome®

Acknowledgements

The authors thank Prof. Naoto Oku, Dr. Tomohiro Asai, and Dr. Kosuke Shimizu from School of Pharmaceutical Sciences, University of Shizuoka for the research of PGlcUA-modified and APRPG-PEG-modified liposomes.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.