Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey

Abstract

Aged individuals experience decreased fine motor function of the hand and digits, which could result, in part, from the chronic, systemic state of inflammation that occurs with aging. Recent research for treating age-related inflammation has focused on the effects of nutraceuticals that have anti-inflammatory properties. One particular dietary polyphenol, curcumin, the principal curcuminoid of the spice turmeric, has been shown to have significant anti-inflammatory effects and there is mounting evidence that curcumin may serve to reduce systemic inflammation. Therefore, it could be useful for alleviating age-related impairments in fine motor function. To test this hypothesis we assessed the efficacy of a dietary intervention with a commercially available optimized curcumin to ameliorate or delay the effects of aging on fine motor function of the hand of rhesus monkeys. We administered oral daily doses of curcumin or a control vehicle to 11 monkeys over a 14- to 18-month period in which they completed two rounds of fine motor function testing. The monkeys receiving curcumin were significantly faster at retrieving a food reward by round 2 of testing than monkeys receiving a control vehicle. Further, the monkeys receiving curcumin demonstrated a greater degree of improvement in performance on our fine motor task by round 2 of testing than monkeys receiving a control vehicle. These findings reveal that fine motor function of the hand and digits is improved in middle-aged monkeys receiving chronic daily administration of curcumin.

Keywords:

• Curcumin
• inflammation
• motor function
• rhesus monkey

Acknowledgements

The authors would like to thank Verdure Sciences for their generous donation of the Longvida Curcumin and control vehicle used in this study. The authors would also like to thank Reese Edwards and Karen Slater for their technical assistance with this study.

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

This study was supported by National Institutes of Health – National Institute of Aging [R01-AG043478-02] and [R01-AG043640-05].