http://orcid.org/0000-0002-7750-6339
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Abstract
Deltamethrin is a pyrethroid insecticide that is considered extremely toxic to aquatic organisms. We evaluated the effect of subacute doses (0.033, 0.1, or 0.3 mg/kg) of deltamethrin on micronucleus frequency and oxidative stress markers in Rainbow Trout Oncorhynchus mykiss at 1, 2, 3, 4, and 8 d after intracoelomic injection. No genotoxic damage was recorded, as no specimen showed a micronucleus number above the physiological range. Deltamethrin exposure elicited a transient reduction in the levels of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase and a persistent decrease in glutathione reductase activity. Overall, the lower antioxidant enzyme activity in the deltamethrin-treated fish was mainly dose-dependent.
Received May 27, 2016 accepted June 18, 2017 Published online August 9, 2017
ACKNOWLEDGMENTS
This study was financially supported by the State Veterinary Institute, Turin, Italy. We wish to thank Laura Gasco (Department of Agricultural, Forest, and Food Sciences, University of Turin) for technical assistance. The authors have no potential conflicts of interest to declare.