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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 31, 2018 - Issue 3
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Case Studies

Acute kidney injury and undiagnosed immunoglobulin A nephropathy after dabigatran therapy

, MD, , MD, , MD, , MD, PhD, , MD, PhD & , MD, MPH, DrPH
Pages 321-323 | Received 22 Nov 2017, Accepted 02 Apr 2018, Published online: 09 May 2018
 

ABSTRACT

Dabigatran, a new oral anticoagulant, is a direct thrombin inhibitor used as an alternative to warfarin to reduce the risk of stroke and systemic embolism with nonvalvular atrial fibrillation. We report a case of a man who resumed dabigatran after 6 weeks of prior therapy and began experiencing hematuria with worsening kidney function. Renal biopsy with immunofluorescence and electron microscopy showed mesangial deposits consistent with immunoglobulin A nephropathy. With discontinuation of dabigatran and addition of methylprednisolone, the gross hematuria cleared and urine output improved.

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