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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 34, 2021 - Issue 1
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Case Studies

Statin-induced necrotizing autoimmune myopathy

Syed A. Hudaa Department of Internal Medicine, State University of New York Upstate Medical University, Syracuse, New YorkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2605-8273
, MBBSORCID Icon,
Sanjay Yadavaa Department of Internal Medicine, State University of New York Upstate Medical University, Syracuse, New YorkORCID Iconhttps://orcid.org/0000-0003-0097-8802
, MBBSORCID Icon,
Sara Kahlownb Department of Internal Medicine, UHS Wilson Medical Center, Johnson City, New York
, MBBS,
Muhammad S. Farooqic Department of Internal Medicine, Mayo Hospital, Lahore, Pakistan
, MBBS,
Stephanie Bryantd Department of Pathology, State University of New York Upstate Medical University, Syracuse, New York
, MD &
Ronald Russoa Department of Internal Medicine, State University of New York Upstate Medical University, Syracuse, New York
, MD
Pages 185-186 | Received 22 Jul 2020, Accepted 29 Sep 2020, Published online: 21 Oct 2020
 
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Abstract

Statins are the most widely used class of drug in the United States. They lower blood cholesterol levels by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Common side effects include myalgias and a mild increase in liver function tests. Statin-induced necrotizing autoimmune myopathy (SINAM) is a very rare side effect that is independent of the type and duration of statin use. Treatment involves high-dose steroids and immunosuppressants such as azathioprine, methotrexate, or mycophenolate mofetil. Nonresponders and patients with severe weakness can be treated with intravenous immunoglobulin or rituximab. We present a case of SINAM that was successfully treated with intravenous immunoglobulin.

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