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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 34, 2021 - Issue 3
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Case Studies

Central nervous system intravascular lymphoma leading to rapidly progressive dementia

Christie G. Turina Department of Medicine, Baylor College of Medicine, Houston, TexasCorrespondence[email protected]
, MD,
Kevin Tinga Department of Medicine, Baylor College of Medicine, Houston, Texas
, MD,
Anthony Bradshawb Department of Neurology, Baylor College of Medicine, Houston, Texas
, MD,
S. Richard Dunhamb Department of Neurology, Baylor College of Medicine, Houston, Texas
, MD,
Karen Nunez-Wallaceb Department of Neurology, Baylor College of Medicine, Houston, Texas
, MD,
Shital M. Patelc Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas
, MD,
Priti Dangayacha Department of Medicine, Baylor College of Medicine, Houston, Texas
, MD,
Stephanie Holdenerd Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas
, MD &
Weei-Chin Lina Department of Medicine, Baylor College of Medicine, Houston, Texas;e Division of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas
, MD, PhD show all
Pages 373-375 | Received 30 Oct 2020, Accepted 14 Dec 2020, Published online: 11 Jan 2021
 
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Abstract

Intravascular lymphoma is an uncommon subtype of B-cell lymphoma with neoplastic cells limited to the lumen of small blood vessels. We report a case of a 52-year-old man who presented with constitutional symptoms and rapidly progressive dementia. He was found to have diffuse leptomeningeal and faint parenchymal enhancement on magnetic resonance imaging and was subsequently diagnosed with intravascular lymphoma following a brain biopsy. He responded remarkably well to systemic and intrathecal chemotherapy. The diagnosis and treatment of intravascular lymphoma have been guided by a few case reports and are largely based on expert opinion.

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