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Journal of Biomaterials Science, Polymer Edition Volume 24, 2013 - Issue 7
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Articles

Deposition of PLA/CDHA composite coating via electrospraying

Huan Zhou Department of Bioengineering, The University of Toledo, Toledo, OH, 43606, USA; Department of Mechanical, Industrial and Manufacturing Engineering, The University of Toledo, Toledo, OH, 43606, USACorrespondence[email protected]
&
Sarit B. Bhaduri Department of Mechanical, Industrial and Manufacturing Engineering, The University of Toledo, Toledo, OH, 43606, USA; Department of Surgery (Dentistry), The University of Toledo, Toledo, OH, 43606, USA
Pages 784-796 | Received 18 May 2012, Accepted 19 Jul 2012, Published online: 08 Aug 2012
 
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Abstract

Composite coatings composed of carbonated calcium deficient hydroxyapatite (CDHA) and polylactic acid (PLA) were deposited on a PLA substrate surface via electrospraying. The operation parameters, structural properties, bioactivity, cell adhesion, and growth capability of as-fabricated PLA/CDHA coatings were investigated. The composite coating showed good biocompatibility and bioactivity. The deposited coating was also applied as a carrier to assist alendronate sodium (AS) local release. AS, an approved bisphosphonate drug used for the treatment of osteoporosis, was incorporated into a composite coating matrix via coelectrospraying. Its release behavior showed a long-term sustained release. This approach can be a potential coating technique for the surface modification of biopolymer implants.

Acknowledgment

This work is partially supported by NSF grant 0700306.

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