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Journal of Biomaterials Science, Polymer Edition Volume 24, 2013 - Issue 18
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Articles

PEG-silica-modified gold nanorods that retain their optical properties in tumor tissues

Yasuyuki AkiyamaDepartment of Applied Chemistry, Faculty of Engineering Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
,
Yasuro NiidomeDepartment of Applied Chemistry, Faculty of Engineering Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
,
Takeshi MoriDepartment of Applied Chemistry, Faculty of Engineering Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
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Yoshiki KatayamaDepartment of Applied Chemistry, Faculty of Engineering Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.;Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.;International Research Center for Molecular System, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.;Center for Advanced Medical Innovation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
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Takuro NiidomeGraduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan.Correspondence[email protected]
Pages 2071-2080 | Received 19 May 2013, Accepted 03 Jul 2013, Published online: 05 Aug 2013
 
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Abstract

Gold nanorods modified with polyethylene glycol (PEG) chains via Au–S bonds form aggregates, and their absorption spectra broaden in tumor tissues. In contrast, the gold nanorods modified here via the crosslinking of PEG chains on the silica shell on gold nanorods showed enhanced permeability and retention effects and retained the optical properties of the original gold nanorods in tumor tissues.

Acknowledgments

This research was supported by a Grant-in-Aid of Scientific Research (B) (No. 22300158) and a Grant-in-Aid for Challenging Exploratory Research (No. 23650266) from the Japan Society for the Promotion of Science (JSPS).

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