Biocompatible hyperbranched polyester magnetic nanocarrier for stimuli-responsive drug release

Abstract

A novel biocompatible magnetic nanocomposite drug carrier was developed by first chemically modifying a hyperbranched polyester (HBPE) with dodecenyl succinic anhydride (DDSA) functional groups to produce HBPE-DDSA. The magnetic nanocomposite Fe₃O₄/HBPE-DDSA was then synthesized by dispersing superparamagnetic iron oxide (Fe₃O₄) nanoparticles within HBPE-DDSA. The structure and magnetic properties of the nanocomposite were characterized by ¹H NMR, MALDI-MS, XRD, FTIR, TEM, and SQUID analyses. Isoniazid (INH) was selected as a model antituberculosis drug to investigate the in vitro drug release properties of Fe₃O₄/HBPE-DDSA/INH. The cytotoxicity of the magnetic nanocomposites was assessed by CCK-8 assay. The results indicated that Fe₃O₄/HBPE-DDSA is a promising potential drug carrier for a magnetic-targeted drug delivery system.

Keywords:

• Hyperbranched polyester
• magnetic nanocomposites
• magnetic targeted drug delivery system (MTDs)
• biocompatibility

Acknowledgments

We gratefully thank the financial support of the College Industrialization Project of Jiangsu Province, the Colleges and Universities in Jiangsu Province Plans to Graduate Research and Innovation, the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Project of Nanjing Science and Technology.