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Articles

Drug carrier three-layer nanofibrous tube for vascular graft engineering

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Pages 501-507 | Received 20 May 2018, Accepted 24 Jun 2018, Published online: 07 Apr 2019
 

Abstract

Currently available synthetic grafts demonstrate moderate success at the macrovascular level, but there are still challenges at small vascular scale (inner diameter of less than 6 mm). In this paper, silk fibroin (SF)/polyurethane (PU)/SF three-layer drug carrier nanofibrous tubes were developed for blood vessel repair with several advantages over existing designs. Our design consisted of a bionic three-layer microtube that was synthesized from the drug carrier SF and oligomeric proanthocyanidin nanofibers as the inner layer, PU nanofibers as the middle layer, and SF nanofibers as the outer layer. The results suggested that these three-layer tubes are attractive biocompatible materials for use as vascular grafts.

Acknowledgements

We thank Natasha Lundin, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

Additional information

Funding

This work was supported by a Grant-in-Aid for the Shinshu University Advanced Leading Graduate Program from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.

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