581
Views
5
CrossRef citations to date
0
Altmetric
Articles

A dual pH and redox-responsive Ag/AgO/carboxymethyl chitosan composite hydrogel for controlled dual drug delivery

, , , , &
Pages 1706-1721 | Received 11 Feb 2020, Accepted 22 May 2020, Published online: 02 Jul 2020
 

Abstract

A pH and redox dual-responsive composite hydrogel was developed, which was formed from triblock copolymer PEG-SS-PCL-SS-PEG and Ag/AgO/carboxymethyl chitosan (CMCS) hydrogel inclusion complexes. Dithiodipropionic acid and poly(ethylene glycol) (PEG) were esterified to synthesize a hydrophilic segment PEG-SS-COOH polymer containing a disulfide bond, and ε-caprolactone is ring-opened in Ar atmosphere to obtain a hydrophobic segment HO-PCL-OH homopolymer. The PEG-SS-PCL-SS-PEG triblock polymers were prepared by reacting the two in a certain ratio, and spontaneously assembled into micelles in an aqueous solution. Ag/AgO/CMCS composite hydrogels with a pH and redox dual-responsive were prepared by dispersing aspirin-loaded micelles into an Ag/AgO/CMCS hydrogel network loaded with another hydrophilic drug ciprofloxacin hydrochloride (CIP). The results showed that the micelles had redox sensitivity due to the insertion of disulfide bonds, and had certain stability within 24 h without reducing substances. In vitro simulated drug release test of composite hydrogel showed that the hydrogel network swelled or degraded, the micelles were lysed, and the release of the drug was triggered when the composite hydrogels were exposed to the micro-environment with high pH or high DTT concentration. Therefore, this composite hydrogel could potentially be one of the candidate materials for the dual drug delivery system.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (21978027).

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 503.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.