Recent advances in microbeads-based drug delivery system for achieving controlled drug release

Abstract

Novel drug delivery system endows a beneficial method for achieving a desired drug concentration at the appropriate site in the body. The concept of targeted drug delivery has been emerged to localize the drug in the targeted tissue of interest while reducing the relative concentration of the medication in the surrounding tissues. This could be easily accomplished by using different multi-particulate dosage forms like pellets, granules, microcapsules, liposomes, beads. But the major drawbacks associated with them are the use of harsh chemicals and an elevated temperature for their preparation. Preparation of microbeads by ionotropic gelation and emulsion gelation method overcomes these problems by neither using harsh chemicals nor elevated temperature for their preparation. Thus, this can be proved to be a better alternative over other dosage forms. Several parameters were studied in terms of their morphology, particle size, encapsulation efficiency, swelling ratio, mucoadhesivity, etc. The endeavor of present article is toward presenting a wider perspective of the comprehensive knowledge available in the field of microbeads. Thus, the intent of this review is to recapitulate the relevance of microbeads.

Keywords:

• Microbeads
• multiparticulate drug delivery system
• ionotropic gelation method
• emulsion gelation method
• polymers

Acknowledgements

The author (Z. Khan) is thankful to DST-FIRST for providing departmental and instrumental facilities and DST- purse for providing fellowship from December 2017 to May 2019. He grateful to ICMR for providing senior research fellowship to Zafar khan (ICMR-SRF-45/40/2019-NAN/BMS).

Disclosure statement

Authors declare no conflict of interest.

Additional information

Funding

The author (Mohammed A.S. Abourehab) would like to thank the Deanship of scientific research at Umm Al-Qura University for supporting this work by grant code (22UQU4290565DSR79).