Abstract
The guided bone regeneration (GBR) technique is the most common and durable approach to repairing bone defects in periodontal surgery. However, membrane exposure causes bacterial infiltration, which lowers the functional integrity of the barrier membrane and destroys bone repair. Here, an antibacterial peptide-modified small intestinal submucosa (SIS) membrane is used as a new GBR membrane for effective bone regeneration. The peptide JH8194 was placed into chitosan microspheres to preserve its stability and allow for sustained release, which realizes rapid and efficient functional modification of the SIS membrane. Biocompatibility and certain antibacterial activities were found in the modified SIS membrane (SIS@CS-JH8194). Additionally, in vitro experiments showed that SIS@CS-JH8194 promoted the expression of osteogenic-related factors and decreased the secretion of inflammatory factors in rat bone mesenchymal stem cells. In vivo experiments showed that SIS@CS-JH8194 could effectively promote bone regeneration in rat skull defects. In this work, we created a new antibacterial GBR membrane to help avoid postoperative infection and improve bone tissue regeneration.
Disclosure Statement
The authors declare no conflict of interest.
Authors’ contributions
Zihao Liu: Conceptualization, Validation, Investigation, Data curation, Visualization, Supervision. Xinying Yu: Methodology, Validation, Investigation, Visualization, Formal analysis, Writing – original draft, Writing – review and editing. Beibei Ma: Validation, Visualization, Investigation. Yilin Yang: Investigation, Visualization. Yuzhu Mu: Investigation, Data curation. Xuemei Lu: Investigation, Data curation. Minting Li: Investigation, Data curation. Wei Jing: Investigation, Visualization. Pengfei Wei: Investigation, Visualization. Shiqing Ma: Investigation, Funding acquisition. Bo Zhao: Investigation, Visualization. Jiayin Deng: Resources, Project administration.
Correction Statement
This article has been republished with minor changes. These changes do not impact the academic content of the article.