Braided scaffolds with polypyrrole/polydopamine/hydroxyapatite coatings with electrical conductivity and osteogenic properties for bone tissue engineering

Abstract

When impaired bones are grafted with bone scaffolds, the behaviors of osteoblast are dependent on the implant materials and surface morphology. To this end, we modulated the surface morphology of scaffolds that promote cell growth. In this study, ice-template and spraying method methods are employed to coat different proportions of PDA and PPy over the PLA/PVA weaving scaffolds, after which HA is Coated over via the electrochemical deposition, forming weaving scaffolds with electrically conductive PDA/PPy/HA coating. The test results indicate that with a PPy/PDA concentration ratio is 30, the PPy particles are more uniformly distributed on the fiber surface. The scaffolds are wrapped in a HA coating layer with a high purity, and calcium and phosphorus elements are evenly dispersed with a Ca/P ratio being 1.69. Owing to the synergistic effect between PDA and PPy coating, the scaffolds demonstrate excellent electrochemical stability and electrochemical activity. The biological activity of the scaffold increased to 274.66% under electrical stimulation. The new thinking proposed by this study extends the worth of applying textile structure to the medical field, the application of which highly increases the prospect of bone tissue engineering.

Keywords:

• Bone tissue engineering
• weaving scaffolds
• polypyrrole
• conductive polymers
• electrochemical deposition

Acknowledgements

We also would like to thank the Analytical & Testing Center of Tiangong University for structured characterization work.

Disclosure statement

No potential conflict of interest was reported by the authors.

Author statement

Ting-ting Li, Shiqi Wang, Jiaxin Li: designed the experiment, experimented, and wrote the manuscript. Assisted with the experiments, and prepared figures and tables. Ying Zhang, Xing Liu, Hao-kai Peng, Liyan Liu, Lu Zhang: Polished the English language. Hai-Tao Ren: Offered suggestions for the characterizations of materials. Lei ling: Corresponding author, Formal analysis, revised the manuscript. Ching-Wen Lou: The corresponding author, Offered Suggestions for the experiments. Jia-Horng Lin: Corresponding author, critical revision of the article, final approval of the article.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (grant numbers 11702187); the Research Fund of China Natural Textile and Apparel Council (grant number 2022033).