Ziziphora clinopodioides extract-loaded chitosan/polyvinylpyrrolidone casting films for potential applications in wound dressings

Abstract

Chitosan/polyvinylpyrrolidone composite films containing hydroalcoholic Ziziphora clinopodioides extract were developed and evaluated for their potential use as wound dressings. The physical and chemical properties of the films were extensively explored, including swelling capacity, mechanical properties, antimicrobial activity, and microstructural characteristics. The results showed that the addition of Ziziphora extract significantly increased the swelling capacity of the films by 561.24% to 1175% (p < 0.05). While tensile strength and Young’s modulus were enhanced, elongation at the breaking point decreased with increasing volume percentages of Ziziphora extract. Variance analysis indicated no statistically significant effect on the tensile properties of the films with varying Ziziphora extract content (p < 0.05). Furthermore, films incorporated with Ziziphora extract demonstrated antimicrobial properties. Scanning electron microscopy (SEM) analysis revealed that samples lacking Ziziphora extract had a smooth surface, while those containing the extract displayed a rough texture that may potentially accelerate the wound healing process.

GRAPHICAL ABSTRACT

Keywords:

• Hydrogel
• chitosan
• polyvinylpyrrolidone
• ziziphora extract
• wound dressing

Disclosure statement

During the preparation of this work the authors used [ChatGPT, Monica] to enhance the grammatical structure and improve sentence flow for readers. After using this tool, the author(s) reviewed and edited the content as needed and take full responsibility for the content of the publication. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Data availability statement

Data will be made available on request.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.