Absorption spectrum for non-invasive blood glucose concentration detection by microwave signals

ABSTRACT

This paper proposes a blood glucose concentration detection method, which is non-invasive and based on the microwave detection technique. This method is harmless to the patients’ body. And the procedure of this method is fast and convenient. The feasibility of this method is verified by obtaining the relationship between the blood glucose level and the absorption spectrum features of the received signals with the range of blood glucose level 0–500 mg/dl. The validity of this method is testified by establishing a simulation model to test the feasibility of this method. The robustness is also checked by achieving the relationship between the peaks of the received signals at 500 MHz in the experiment earlobe phantom with a group of the human blood glucose level ranges from 0-500 mg/dl with the step of 20 mg/dl.

KEYWORDS:

• Microwave detection
• blood glucose measurement
• non-invasive
• absorption spectrum

Acknowledgment

The authors thank the Agilent Open Lab in Beijing for the help of providing Agilent Technologies MXG vector signal generator N5182B and the Oscilloscope Agilent Technologies MSOS804A.

Disclosure statement

No potential conflict of interest was reported by the authors.

ORCID

Qinwei Li http://orcid.org/0000-0002-0471-4209

Additional information

Funding

The authors are grateful to the support of National Natural Science Foundation of China [grant number 61271323].

Notes on contributors

Qinwei Li

Qinwei Li received the B.S. and M.S. degrees in electronic science and technology from Tianjin University, Tianjin, China, in 2012 and 2015, respectively. Currently, she is a Ph.D. student in electronic science and technology at Tianjin University. Her research interests include imaging algorithm, medical imaging and signal processing.

Xia Xiao

Xia Xiao received the Ph.D. degree in 2002 in electronic and information technology from the Technical University of Chemnitz (TU Chemnitz), Chemnitz, Germany, and the M.S. and B.S. degrees in 1996 in condensed physics and in 1993 in physics, respectively, both from Tianjin Normal University, Tianjin, China. In 2002-2003, she joined in the “MIRAI Project” in National Institute of Industrial Science and technology (AIST), Japan, where she worked in the ULSI low-k/Cu interconnect technology as a key researcher. In 2003, she joined the School of Electronic Information Engineering, Tianjin University, where she is currently a Professor. In 2006-2007, she was a visiting professor in Hiroshima University, Hiroshima, Japan, where she worked in developing algorithms for UWB imaging for early breast cancer detection. Her current research interests include advanced algorithms for early breast cancer detection by UWB, non-destructive characterization of film properties by surface acoustic waves (SAWs).

Takamaro Kikkawa

Takamaro Kikkawa received the B.S. and M.S. degrees in electronic engineering from Shizuoka University, Shizuoka, Japan, in 1974 and 1976, respectively, and the Ph.D. degree in electronic system from Tokyo Institute of Technology, Tokyo, Japan in 1994. He joined NEC Corp., Tokyo, Japan in 1976, where he conducted research and development on interconnect technologies for large scale integrated circuits and dynamic random access memories. From 1983 to 1984, he was the Visiting Scientist at Massachusetts Institute of Technology, Cambridge, MA, USA, where he conducted research on SOI transistors. In 1998, he joined the faculty of Hiroshima University, Hiroshima, Japan, where he is Professor of the Graduate School of Advanced Sciences of Matter and Director of the Research Institute for Nanodevice and Bio Systems. He is also Councilor of Hiroshima University. From 2001 to 2008, he was appointed as the Senior Research Scientist at the National Institute of Advanced Industrial Science and Technology, Japan, and the Group Leader of Low-k/Cu Interconnect Technology of Japan's “MIRAI Project”. His research interests include wireless and wired interconnect technologies, impulse-radio-CMOS transceiver circuits with on-chip antennas and impulse-radar-based CMOS breast cancer detection system. Dr. Kikkawa is Fellow of Japan Society of Applied Physics.