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ABSTRACT
In the present work the thermostability and fluorescence peculiarities of the methylene blue complexes with human serum albumin have been studied under the effect of millimeter range electromagnetic waves. For this aim the denaturation of the complexes was measured using the double-beam spectrophotometer Unicam-SP8-100 and the fluorescence measurements were carried out on the spectrofluorometer Cary Eclipse. The albumin solutions were irradiated by electromagnetic waves with 41.8 and 51.8 GHz frequencies. The irradiation was shown to result in the thermostability increasing of the complexes and this effect depends on the frequency. It was also revealed that at the irradiation the fluorescence properties of the methylene blue complexes with albumin change, which, in turn, is connected to the alteration of the protein folding.
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No potential conflict of interest was reported by the authors.
Additional information
Notes on contributors
Mariam A. Shahinyan
Mariam A. Shahinyan - PhD, Researcher at Yerevan State University. The main scientific interest includes the study of influence of millimeter range electromagnetic waves on biological systems being on various levels of organization.
Ara P. Antonyan
Ara P. Antonyan - PhD, Doctor of Biological Sciences, Associate Professor at Yerevan State University. The main scientific interest includes the study of binding peculiarities of multimodal ligands to biomacromolecules, particularly, proteins and nucleic acids.
Vitali P. Kalantaryan
Vitali P. Kalantaryan - PhD, Researcher at Yerevan State University. The main scientific interest includes the study of radio frequency electromagnetic waves as well as their effect of biological systems.
Marieta S. Mikaelyan
Marieta S. Mikaelyan- PhD, Researcher at Yerevan State University. The main scientific interest includes the study of effect of millimeter range electromagnetic waves on biological systems.
Poghos O. Vardevanyan
Poghos O. Vardevanyan- PhD, Doctor of Biological Sciences, Professor, Head of Department of Biophysics of Yerevan State University. The main scientific interest includes the studies of nucleic acids and proteins, binding of various ligands to them as well as the effect of different physical (including millimeter range electromagnetic waves) and chemical factors on biological systems, being on various levels of organization.